If I had read this when I was younger, I would be crying a lot to most of the pages of this story, and would have perhaps been left traumatised. It's a realistic possibility duo to how I was when I had first gotten in to anime and manga.
The way I am though(mature, I do calim to be), it only causes me to be instantly fully awoken up in the mornings when I regain my dream-staggered consciousness , with the first thing on my mind even before I have opened my eyes being the characters of this story.

I remember my first anime, Fate/Stay night, and how for 6 months after having had gone through the story, 8 years ago, I couldn't think of much of anything, other than Saber.
I had fallen in love with her, and she was gone. It doesn't matter if you know Fate/Stay Night or not, it was the feeling of someone you love, and who loves you, not being your possibility simply because the world doesn't allow it(not in the sense that I was actually wishing for an anime character to be alive (I WAS(I DO), DEFINITELY), but in the sense of that what happened in the story I had projected on to myself).

Another example.

5 Centimeters per second.
That, I've gone through only less than a year ago, and as rugged as I've developed to be, due to my age and the amount of stories that I have gone through thus far, 5 Centimeters per second made me feel alive, really alive.
Alive by not being able to close my eyes at night in my bed even though I was exhausted and tired.
Alive in the way of, I hope you know what it is that I'm going to try to describe now(never quite found an expression to describe the feeling with, not one I was satisfied enough with to have memorised it);
Alive in the way of having the feeling of breathing being really difficult.
Having to, not physically, struggle to breathe in. That compressing feeling of sadness and knowing that what is making you sad is reality itself.

Kuzu no Honkai is basically the two things that I have described above, from start to finish(though the manga is not yet over, at the time of writing this).
To draw a line with a metaphorical comparison..
You, the reader, are a freshly open wound. No, that's not good, naturally you don't have such kinds of wounds, hopefully..
This story is, a stick, doesn't matter what really, but something solid.
This story pokes at your heart, if you read it sincerily.
It's like poking at the inside of your flesh, but in a sense of thought, your mental state.
Do you get sick with sadness by the thought of the person you love.. Not loving you.. Leaving you.. Leaving you for another...
If you delve in to this story with full respect, the respect I believe you should approach to every story with, the respect that allows you to take the whatever the story is with full sincerity, if you delve in to this story like that, enjoy yourself.
Sadness and happiness are just two sides of the same coin that is life, and this story will make you feel alive very much.


From now on, a heavily interpretation-based segment follows.

This story's premise is people's inner-most workings.
How choices are made, when there is by far not a single positive choice to be had in sight.
The single statement that I want to make, the single thing that makes this work a 10/10 for me;

The characters in this are real people.
More mature for the ages that they are, but that's not a bad thing(at least I wish I was like them when I was of their age).

Altruism, OBJECTIVELY, does not exist.
Everything anyone ever does is the best thing that one can do.
The best thing in the sense of how much you like it, the best thing in the sense of what you gain from it, the best thing in the sense of you losing the least by it.
Everything anyone knows is the world their eyes portray to them.
This work, in the packaging of romance, portrays the the principle of "I live for myself and no one else".
We are ALL SCUM, and only you know it.
We are all scum, but because no one other than yourself will ever be YOU, to peak inside your inner-most depths of thought, no one will ever know you are scum.
"Scum".
That is something I (believe I) know about everyone, but I only see the world through my eyes.

You can never be selfless, you make the decisions you make, and just by making a decision, you were already selfish. Selfish enough to have denied the existence to one possibility, because the the possibility you've chosen suits you better.
People are not pebbles on the river bed.

There would be no heroes if everyone knew the thoughts of anyone.
It would be best, if everyone knew everyone.
But this isn't the End of Evangelion.

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To finalise, Hanabi's (the main charactressess) eyes are stunning. That is to say, the art of the manga is beautiful.
Realistically drawn everything, just as I love it to be.
Realistically drawn beautiful characters manga characters, the best thing.
There is even an occasional.. I don't know what those are called, but like, when the character's face is in one instance drawn really funny just to sympathise e.g. how much that character thinks that what the other character said is stupid! You know, right? Anyways I love those whenever, and in a story such as this one.... It's like being given an ice cube when you have a nasty burn that really hurts..
Also, the way the characters' thoughts are portrayed, the way it's all "folded" in to a manga format, it's so great.
It took me while, but after it, I've started reading the manga as if I were reading three things at the same time.
Reading through reality,
the character that is in the moment the focal point of the story,
and the "heart" of that character.
This might sound confusing for those who're reading this without having had read the manga at least for a bit.