I am a fan of Tsutomu Nihei's works, thus my review might slightly be biased.
Also I can easily say that Blame! is my favourite cyberpunk manga to date which makes most of the similarities in Biomega all the more enjoyable for me.

The protag-kun Zouchi is a synthetic human, meaning like Killy he can take quite the beating and do some badass shit.
And I will be 100% honest and tell that, Biomega's action scenes are nothing short of GLORIOUS. They are a lot easier to follow, more impactful and contrary to Blame! you can see what's going on (Of course I'm exaggerating, I love Blame!'s fight scenes all the same)
Biomega's characters are all so entertaining and loveable (For villains it's not as much, their characters are not fully fleshed out) though you won't get too attached to them (maybe only a few like the cute as hell AI Fuyu) because Biomega was cut short for it's story. Zouchi is a synthetic human being capable of living for hundreds of years and the adventures are vast (Trivia: Blame!'s protagonist synthetic human Killy was alive for more than 3000+ years, no wonder the guy doesn't talk much). So If Nihei-sensei wanted he could easily turn Biomega into a 300+ chapter manga series with ample amount of content to fill the chapters to the brim. But with less than a hundred chapters it sometimes feels rushed and disconnected also not giving some characters enough spotlight when they could easily become fan favorites.
Biomega is a great manga series that I would recommend to any fan of seinen-action genre. Even though it had so much more potential to make it a rival for Blame! It still uses enough of it to make it a memorable read.

BUT ! Biomega has 1 major thing that lacks that is soooooo disappointing to me. It doesn't have a proper wiki page... For Nihei-sensei's works you ALWAYS need wiki. Not gonna lie dude for Blame! I read the entire wiki to really understand the whole thing. And for Sidonia no Kishi it also helped. For Biomega it's not as necessary but it still would be appreciated... Someone get on that.. Thanks.